Motif ID: POU5F1_SOX2{dimer}.p2

Z-value: 1.215


Transcription factors associated with POU5F1_SOX2{dimer}.p2:

Gene SymbolEntrez IDGene Name
POU5F1 5460 POU class 5 homeobox 1
SOX2 6657 SRY (sex determining region Y)-box 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
POU5F1chr6_-_312461590.476.7e-02Click!
SOX2chr3_+_182912769-0.476.9e-02Click!


Activity profile for motif POU5F1_SOX2{dimer}.p2.

activity profile for motif POU5F1_SOX2{dimer}.p2


Sorted Z-values histogram for motif POU5F1_SOX2{dimer}.p2

Sorted Z-values for motif POU5F1_SOX2{dimer}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of POU5F1_SOX2{dimer}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_27508139 2.940 LOC643401
hypothetical protein LOC643401
chr4_+_74493918 2.509 ALB
albumin
chr17_+_24394281 2.359 PIPOX
pipecolic acid oxidase
chr6_-_138862273 2.348


chr10_+_7785360 2.241 ITIH2
inter-alpha (globulin) inhibitor H2
chr10_+_7785235 2.171 NM_002216
ITIH2
inter-alpha (globulin) inhibitor H2
chr10_+_7785290 2.168 ITIH2
inter-alpha (globulin) inhibitor H2
chr10_+_7785331 2.094 ITIH2
inter-alpha (globulin) inhibitor H2
chr4_+_74493174 2.035 ALB
albumin
chr17_+_24394043 2.025 NM_016518
PIPOX
pipecolic acid oxidase
chr6_+_24465109 1.977 NM_181337
KAAG1
kidney associated antigen 1
chr4_+_100714995 1.906 MTTP
microsomal triglyceride transfer protein
chr6_+_132000134 1.818 NM_005021
ENPP3
ectonucleotide pyrophosphatase/phosphodiesterase 3
chr4_+_74493331 1.763 ALB
albumin
chr3_+_186529376 1.665 MAP3K13
mitogen-activated protein kinase kinase kinase 13
chr8_-_17797127 1.565 NM_147203
NM_201553
NM_004467
NM_201552
FGL1



fibrinogen-like 1



chr4_+_74493266 1.562 ALB
albumin
chr16_-_54424517 1.541 NM_001025194
NM_001025195
NM_001266
CES1


carboxylesterase 1


chr4_+_74493218 1.423 ALB
albumin
chr21_+_41663853 1.395 MX2
myxovirus (influenza virus) resistance 2 (mouse)
chr2_+_233443237 1.393 NM_206895
C2orf82
chromosome 2 open reading frame 82
chr2_+_169367345 1.393 NM_001039724
NM_001171632
NM_052946
NOSTRIN


nitric oxide synthase trafficker


chr19_-_53081326 1.324 SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr1_+_57093030 1.294 NM_000562
C8A
complement component 8, alpha polypeptide
chr19_-_5789740 1.271 FUT6
fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
chr10_+_4995685 1.265 AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr4_+_74493301 1.237 ALB
albumin
chr3_-_150422474 1.231 NM_000096
CP
ceruloplasmin (ferroxidase)
chr2_+_113601616 1.225 IL1RN
interleukin 1 receptor antagonist
chr11_-_16380967 1.188 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr2_+_138438277 1.177 NM_001024074
NM_001024075
NM_006895
HNMT


histamine N-methyltransferase


chr10_-_5035967 1.173 NM_001135241
AKR1C1
AKR1C2
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
chr2_+_128644510 1.159 UGGT1
UDP-glucose glycoprotein glucosyltransferase 1
chr2_+_113601608 1.139 NM_173842
IL1RN
interleukin 1 receptor antagonist
chr16_+_70646008 1.122 NM_001126102
NM_005143
HP

haptoglobin

chr14_+_38772870 1.094 NM_054024
MIA2
melanoma inhibitory activity 2
chr10_-_52315436 1.088 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr6_+_26264531 1.075 HIST1H1E
histone cluster 1, H1e
chr6_+_26264537 1.042 NM_005321
HIST1H1E
histone cluster 1, H1e
chr6_-_43384507 1.018 NM_206922
CRIP3
cysteine-rich protein 3
chrX_-_55037235 1.002 NM_002625
PFKFB1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr17_-_76720342 0.923 AATK
apoptosis-associated tyrosine kinase
chr13_+_96592051 0.911 MBNL2
muscleblind-like 2 (Drosophila)
chr17_+_3324096 0.910 NM_001128085
ASPA
aspartoacylase
chr1_+_144149794 0.880 NM_006472
TXNIP
thioredoxin interacting protein
chr10_+_4995597 0.879 AKR1C1
AKR1C3
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr2_-_238813284 0.876 HES6
hairy and enhancer of split 6 (Drosophila)
chr9_+_134843918 0.867 NM_001135031
NM_004188
GFI1B

growth factor independent 1B transcription repressor

chr6_+_131190237 0.847 NM_001195597
LOC285733
hypothetical LOC285733
chr12_-_14887648 0.817 NM_021071
ART4
ADP-ribosyltransferase 4 (Dombrock blood group)
chr21_+_39117064 0.804 ETS2
v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
chr10_-_69267774 0.788 NM_021800
NM_201262
DNAJC12

DnaJ (Hsp40) homolog, subfamily C, member 12

chr6_-_138862271 0.780 NM_001144060
NHSL1
NHS-like 1
chr2_-_238813365 0.769 NM_001142853
NM_018645
HES6

hairy and enhancer of split 6 (Drosophila)

chr7_+_29486010 0.760 NM_001039936
CHN2
chimerin (chimaerin) 2
chr14_+_22859236 0.752 NM_004643
PABPN1
poly(A) binding protein, nuclear 1
chr3_-_42892195 0.751 CYP8B1
cytochrome P450, family 8, subfamily B, polypeptide 1
chr8_+_39890484 0.738 NM_002164
IDO1
indoleamine 2,3-dioxygenase 1
chr10_+_4995453 0.730 NM_001353
AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr16_-_45339605 0.726 NM_182493
MYLK3
myosin light chain kinase 3
chr1_+_165564904 0.719 NM_001198783
POU2F1
POU class 2 homeobox 1
chr4_+_187424336 0.714 F11
coagulation factor XI
chr10_+_7785347 0.710 ITIH2
inter-alpha (globulin) inhibitor H2
chr9_-_14900992 0.705 NM_144966
FREM1
FRAS1 related extracellular matrix 1
chr18_-_3001944 0.700 NM_014646
LPIN2
lipin 2
chr1_-_1701313 0.699 NM_001198994
NADK
NAD kinase
chr6_+_26212082 0.689 NM_003542
HIST1H4C
histone cluster 1, H4c
chr4_+_88076418 0.663


chr15_+_63124760 0.658 NM_178859
OSTBETA
organic solute transporter beta
chr14_+_31868229 0.654 NM_004274
AKAP6
A kinase (PRKA) anchor protein 6
chr1_-_229071957 0.640 NM_001136494
C1orf198
chromosome 1 open reading frame 198
chr9_-_103185621 0.637 NM_001127610
BAAT
bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
chr4_-_187881977 0.632 NM_005245
FAT1
FAT tumor suppressor homolog 1 (Drosophila)
chr10_+_114123765 0.627 ACSL5
acyl-CoA synthetase long-chain family member 5
chr18_-_3835295 0.624 NM_001003809
DLGAP1
discs, large (Drosophila) homolog-associated protein 1
chr13_-_27441143 0.620 CDX2
caudal type homeobox 2
chr4_+_17125885 0.613 NM_001079827
CLRN2
clarin 2
chr1_+_559129 0.613


chr1_+_165565006 0.609 POU2F1
POU class 2 homeobox 1
chr4_-_110942783 0.598 NM_000204
CFI
complement factor I
chr4_-_186970366 0.594 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr13_-_27441290 0.591 NM_001265
CDX2
caudal type homeobox 2
chr5_+_176449156 0.570 NM_022963
FGFR4
fibroblast growth factor receptor 4
chr2_-_74915722 0.568


chr1_+_43063817 0.565 NM_018538
ERMAP
erythroblast membrane-associated protein (Scianna blood group)
chr12_-_121753795 0.562 NM_177551
GPR109A
G protein-coupled receptor 109A
chr5_+_140709907 0.561 NM_018922
NM_032095
PCDHGB1

protocadherin gamma subfamily B, 1

chr4_-_41445479 0.539 PHOX2B
paired-like homeobox 2b
chr6_+_64344307 0.537 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chrX_+_7147471 0.534 NM_000351
STS
steroid sulfatase (microsomal), isozyme S
chr1_-_177106702 0.526 NM_004673
ANGPTL1
angiopoietin-like 1
chr11_+_63829616 0.513 NM_004451
ESRRA
estrogen-related receptor alpha
chr22_+_16423147 0.509 NM_031481
SLC25A18
solute carrier family 25 (mitochondrial carrier), member 18
chr4_+_88939725 0.509 NM_004967
IBSP
integrin-binding sialoprotein
chr1_+_50347176 0.508 NM_001144774
NM_021952
ELAVL4

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)

chr2_+_228386800 0.501 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr1_+_61315516 0.499 NM_001145511
NFIA
nuclear factor I/A
chr9_+_130724382 0.498 NM_001100877
PHYHD1
phytanoyl-CoA dioxygenase domain containing 1
chr1_+_61315378 0.495


chr1_-_100003936 0.492 NM_001013660
FRRS1
ferric-chelate reductase 1
chr4_+_114433551 0.478 ANK2
ankyrin 2, neuronal
chr2_-_188086612 0.476 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr18_-_73834670 0.476


chr7_+_1092968 0.472 NM_001039966
NM_001505
GPER

G protein-coupled estrogen receptor 1

chr17_-_64649608 0.468 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr4_+_74500748 0.464 ALB
albumin
chr10_-_11614279 0.461 NM_001080491
USP6NL
USP6 N-terminal like
chr3_-_102522093 0.461 NM_016247
IMPG2
interphotoreceptor matrix proteoglycan 2
chr4_+_187424111 0.458 NM_000128
F11
coagulation factor XI
chr7_-_1562272 0.455 NM_001097620
TMEM184A
transmembrane protein 184A
chr10_-_73518772 0.454 NM_001134434
NM_014767
SPOCK2

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2

chr13_-_27441423 0.446 CDX2
caudal type homeobox 2
chr2_-_215949566 0.440 FN1
fibronectin 1
chr2_+_176842368 0.439 NM_006554
MTX2
metaxin 2
chr4_-_88076328 0.439


chr4_-_176970372 0.438 GPM6A
glycoprotein M6A
chr14_+_87560646 0.437 LOC283587
hypothetical protein LOC283587
chr16_+_52081836 0.433 RBL2
retinoblastoma-like 2 (p130)
chr4_+_70831387 0.430 NM_001025104
NM_001890
CSN1S1

casein alpha s1

chr21_-_38415273 0.421 NM_005867
DSCR4
Down syndrome critical region gene 4
chr3_-_156904690 0.421 NM_014996
PLCH1
phospholipase C, eta 1
chr9_+_2707525 0.415 NM_133497
KCNV2
potassium channel, subfamily V, member 2
chr11_-_55987452 0.412 NM_001004743
OR5M9
olfactory receptor, family 5, subfamily M, member 9
chr10_+_114123828 0.411 NM_203379
ACSL5
acyl-CoA synthetase long-chain family member 5
chr10_-_5436781 0.409 NM_001171864
NM_024803
TUBAL3

tubulin, alpha-like 3

chr1_-_155936904 0.405 NM_052939
FCRL3
Fc receptor-like 3
chr18_-_59462469 0.403 NM_002974
SERPINB4
serpin peptidase inhibitor, clade B (ovalbumin), member 4
chr2_+_204509698 0.390 NM_012092
ICOS
inducible T-cell co-stimulator
chr4_-_68793928 0.390 NM_182502
TMPRSS11B
transmembrane protease, serine 11B
chr14_-_19252330 0.385 NM_001197287
OR11H2
olfactory receptor, family 11, subfamily H, member 2
chr15_+_63701322 0.384 NM_004727
SLC24A1
solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
chr2_-_218865451 0.379 NM_022152
TMBIM1
transmembrane BAX inhibitor motif containing 1
chr5_+_140719773 0.373 NM_018923
NM_032096
PCDHGB2

protocadherin gamma subfamily B, 2

chr14_+_38720085 0.370 PNN
pinin, desmosome associated protein
chr10_+_77212524 0.365 NM_032024
C10orf11
chromosome 10 open reading frame 11
chr11_+_55362802 0.362 NM_001005496
OR5D16
olfactory receptor, family 5, subfamily D, member 16
chr20_-_9767406 0.361 NM_020341
NM_177990
PAK7

p21 protein (Cdc42/Rac)-activated kinase 7

chr17_-_38385511 0.357 NM_025267
AARSD1
alanyl-tRNA synthetase domain containing 1
chr7_-_16811131 0.347 NM_006408
AGR2
anterior gradient homolog 2 (Xenopus laevis)
chr3_+_45902999 0.346 NM_006641
NM_031200
CCR9

chemokine (C-C motif) receptor 9

chr18_+_9092618 0.344 NM_021074
NDUFV2
NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa
chr1_-_180627934 0.343 NM_001033044
NM_002065
GLUL

glutamate-ammonia ligase

chr6_+_64414389 0.342 NM_015153
PHF3
PHD finger protein 3
chr2_-_152392935 0.341 ARL5A
ADP-ribosylation factor-like 5A
chr6_+_126282078 0.339 NCOA7
nuclear receptor coactivator 7
chr9_-_115877104 0.338 AMBP
alpha-1-microglobulin/bikunin precursor
chr18_-_72221228 0.336 ZNF516
zinc finger protein 516
chr17_-_43254117 0.335 OSBPL7
oxysterol binding protein-like 7
chr16_-_55111275 0.334 BBS2
Bardet-Biedl syndrome 2
chr6_+_88021644 0.333 ZNF292
zinc finger protein 292
chr20_+_16312 0.332 NM_153325
DEFB125
defensin, beta 125
chr7_+_80105907 0.332 CD36
CD36 molecule (thrombospondin receptor)
chr4_-_155731288 0.329 NM_000508
NM_021871
FGA

fibrinogen alpha chain

chr20_-_44151971 0.329 NM_020967
NCOA5
nuclear receptor coactivator 5
chr5_+_161210280 0.328 NM_001127648
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr12_+_25096472 0.328 NM_006152
LRMP
lymphoid-restricted membrane protein
chr4_-_176970407 0.328 GPM6A
glycoprotein M6A
chr17_-_43254132 0.327 NM_145798
OSBPL7
oxysterol binding protein-like 7
chr2_-_157890400 0.325 NM_020711
ERMN
ermin, ERM-like protein
chr4_+_140806536 0.325 MGST2
microsomal glutathione S-transferase 2
chr1_+_153222393 0.323 NM_001184891
NM_001184892
NM_025207
NM_201398
FLAD1



FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae)



chr10_+_114033403 0.323 NM_058222
TECTB
tectorin beta
chr20_+_18742369 0.322 NM_178483
C20orf79
chromosome 20 open reading frame 79
chr20_+_57966865 0.321 NM_177980
CDH26
cadherin 26
chr11_+_20001130 0.321 NM_001111019
NAV2
neuron navigator 2
chr1_-_41398126 0.317 NM_001172222
SCMH1
sex comb on midleg homolog 1 (Drosophila)
chr18_+_27425727 0.316 NM_000371
TTR
transthyretin
chr3_-_173723754 0.314 NM_001190943
NM_001190942
NM_003810
TNFSF10


tumor necrosis factor (ligand) superfamily, member 10


chr6_-_116707778 0.313 TSPYL1
TSPY-like 1
chr3_-_9895633 0.312 NM_022094
CIDEC
cell death-inducing DFFA-like effector c
chr2_+_143351695 0.311 KYNU
kynureninase
chr4_+_74520796 0.310 NM_001134
AFP
alpha-fetoprotein
chr2_+_132196533 0.309 NM_013310
C2orf27A
chromosome 2 open reading frame 27A
chr20_+_39402834 0.309 NM_022896
LPIN3
lipin 3
chr7_+_80105718 0.308 NM_000072
NM_001001548
CD36

CD36 molecule (thrombospondin receptor)

chr2_+_89715037 0.308


chr1_+_153222464 0.308 FLAD1
FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae)
chr8_+_92184022 0.307 NM_001129890
LRRC69
leucine rich repeat containing 69
chr16_+_82540172 0.307 NM_013370
NM_182980
OSGIN1

oxidative stress induced growth inhibitor 1

chr6_-_88917600 0.303 NM_001160260
CNR1
cannabinoid receptor 1 (brain)
chr2_-_233349469 0.300 NM_001172416
NM_001172417
NM_002242
KCNJ13


potassium inwardly-rectifying channel, subfamily J, member 13


chr17_-_15463742 0.300 NM_006382
CDRT1
CMT1A duplicated region transcript 1
chr1_-_149214063 0.298 NM_022075
NM_181746
LASS2

LAG1 homolog, ceramide synthase 2

chr2_-_43919392 0.296 NM_022436
ABCG5
ATP-binding cassette, sub-family G (WHITE), member 5
chr1_+_559618 0.294


chr2_-_180135559 0.292 NM_001113398
ZNF385B
zinc finger protein 385B
chr13_+_23042722 0.292 NM_148957
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr10_+_101532450 0.289 NM_000392
ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr20_-_44151952 0.288 NCOA5
nuclear receptor coactivator 5
chr12_-_6354650 0.284 NM_001159576
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr1_+_156842852 0.284 NM_001004478
OR10Z1
olfactory receptor, family 10, subfamily Z, member 1
chr12_+_61645361 0.283 RPL14
ribosomal protein L14
chr14_+_38719462 0.281 PNN
pinin, desmosome associated protein
chr19_-_5790702 0.278 NM_000150
NM_001040701
FUT6

fucosyltransferase 6 (alpha (1,3) fucosyltransferase)

chrX_+_79562601 0.278 NM_152630
FAM46D
family with sequence similarity 46, member D
chr2_+_73973640 0.277 ACTG2
actin, gamma 2, smooth muscle, enteric
chr13_+_108079570 0.275 NM_001198950
MYO16
myosin XVI
chr2_-_37397669 0.274 NM_005813
PRKD3
protein kinase D3
chr11_+_82078217 0.273


chr12_+_49634048 0.269 NM_001109619
HIGD1C
HIG1 hypoxia inducible domain family, member 1C

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.69 2.46e-06 GO:0007606 sensory perception of chemical stimulus
2.74 7.94e-06 GO:0007608 sensory perception of smell
1.30 2.70e-03 GO:0032501 multicellular organismal process
1.93 2.97e-03 GO:0007600 sensory perception
5.14 4.45e-03 GO:0072376 protein activation cascade
1.60 4.34e-02 GO:0050877 neurological system process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.32 1.20e-03 GO:0071944 cell periphery
1.31 2.36e-03 GO:0005886 plasma membrane
1.46 6.40e-03 GO:0005576 extracellular region
1.61 4.34e-02 GO:0044421 extracellular region part

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.80 1.62e-06 GO:0004984 olfactory receptor activity
1.80 5.24e-05 GO:0004888 transmembrane receptor activity
1.99 1.04e-04 GO:0004930 G-protein coupled receptor activity
1.54 6.00e-04 GO:0004871 signal transducer activity
1.54 6.00e-04 GO:0060089 molecular transducer activity
1.60 7.92e-04 GO:0004872 receptor activity